2023
48. Baringer SL, Lukacher AS, Palsa K, Kim H, Lippmann ES, Spiegelman VS, Simpson IA, and Connor JR. “Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin.” Journal of Neurochemistry 167:248-261 (2023).
47. Curry CW, Sturgeon SM, O’Grady BJ, Yates AK, Kjar A, Paige HA, Mowery LS, Katdare KA, Patel RV, Mlouk K, Stiefbold MR, Vafaie-Partin S, Kawabata A, McKee RM, Moore-Lotridge S, Hawkes A, Kusunose J, Gibson-Corley KN, Schmeckpeper J, Schoenecker JG, Caskey CF, and Lippmann ES. “Growth factor-free, peptide-functionalized gelatin hydrogel promotes arteriogenesis and attenuates tissue damage in a murine model of critical limb ischemia.” Biomaterials 303:122397 (2023).
46. Romero-Fernandez W, Carvajal-Tapia C, Prusky A, Katdare KA, Wang E, Shostak A, Ventura-Antunes L, Harmsen HJ, Lippmann ES, Fuxe K, MacGurn JA, Borroto-Escuela DO, and Schrag MS. “Detection, visualization and quantification of protein complexes in human Alzheimer’s disease brains using proximity ligation assay.” Scientific Reports. 13:11948 (2023).
45. Allchin ER, Rosch JC, Stoneman AD, Kim H, and Lippmann ES. “Generalized strategy for engineering mammalian cell-compatible RNA-based biosensors from random sequence libraries.” ACS Sensors. 8:2079-2086 (2023).
2022
44. Kim H, Leng K, Park J, Sorets AG, Kim S, Shostak A, Embalabala RJ, Mlouk K, Katdare KA, Rose IVL, Sturgeon SM, Neal EH, Ao Y, Wang S, Sofroniew MV, Brunger JM, McMahon DG, Schrag MS, Kampmann M, and Lippmann ES. “Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin.” Nature Communications 13:6851 (2022).
43. Leng K*, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, TCW J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, and Kampmann M*. “CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states.” Nature Neuroscience 25:1528-1542 (2022). (* Co-corresponding author)
42. Challa AP*, Niu X, Garrison EA, Van Driest SL, Bastarache LM, Lippmann ES, Lavieri RR, Goldstein JA, and Aronoff DM*. “Medication history-wide association studies for pharmacovigilance of pregnant patients.” Communications Medicine 2:115 (2022). (* Co-corresponding author)
41. Shi Y, Kim H, Hamann CA, Rhea EM, Brunger JM, and Lippmann ES. “Nuclear receptor ligand screening in an iPSC-derived in vitro blood-brain barrier model identifies new contributors to leptin transport.” Fluids Barriers CNS 19:77 (2022).
40. Rosch JC#, Hoogenboezem EN#, Sorets AG, Duvall CL*, and Lippmann ES*. “Albumin-binding aptamer chimeras for improved siRNA bioavailability.” Cellular and Molecular Bioengineering 15:161-173 (2022). (# Co-first author) (* Co-corresponding author)
39. Rahim M, Nakhe AY, Bosma KJ, Rosch JC, Oeser JK, Wang B, Banerjee DR, Lippmann ES, Jacobson DA, O’Brien RM, and Young JD. “G6PC2 negatively regulates glucose oxidation and insulin secretion in β-cells.” Journal of Biological Chemistry 298:101729 (2022).
2021
38. O’Grady BJ*, Geuy MD, Kim H, Balotin KM, Allchin ER, Florian DC, Bute NN, Scott TE, Lowen GB, Fricker CM, Fitzgerald ML, Guelcher SA, Wikswo JP, Bellan LM, and Lippmann ES*. “Rapid prototyping of cell culture microdevices using parylene-coated 3D prints.” Lab on a Chip 21:4814-4822 (2021). (* Co-corresponding author)
37. Bosworth AM, Kim H, O’Grady KP, Richter I, Lee L, O’Grady BJ, and Lippmann ES. “Influence of substrate stiffness on barrier function in an iPSC-derived in vitro blood-brain barrier model.” Cellular and Molecular Bioengineering 15:31-42 (2021).
36. Neal EH, Katdare KA, Shi Y, Marinelli NA, Hagerla KA, and Lippmann ES. “Influence of basal media composition on barrier fidelity within human pluripotent stem cell-derived blood-brain barrier models.” Journal of Neurochemistry 21:4814-4822 (2021).
2020
35. Lippmann ES, Azarin SM, Palecek SP, and Shusta EV. “Commentary on human pluripotent stem cell-based blood-brain barrier models.” Fluids Barriers CNS 17:64 (2020).
34. O’Grady BJ#, Balotin KM#, Bosworth AM, McClatchey PM, Weinstein RM, Gupta M, Poole KS, Bellan LM*, and Lippmann ES*. “Development of an N-cadherin biofunctionalized hydrogel to support the formation of synaptically connected neural networks.” ACS Biomaterials Science & Engineering 6:5811-5822 (2020). (# Co-first author) (* Co-corresponding author)
33. Rosch JC, Neal EH, Balikov DA, Rahim M, and Lippmann ES. “CRISPR-mediated isogenic cell-SELEX approach for generating highly specific aptamers against native membrane proteins.” Cellular and Molecular Bioengineering 13:559-574 (2020).
32. Sorets AG, Rosch JC, Duvall CL, and Lippmann ES. “Caveolae-mediated transport at the injured blood-brain barrier as an unexplored pathway for central nervous system drug delivery.” Current Opinion in Chemical Engineering 30:86-95 (2020).
31. Challa AP, Lavieri RR, Lippmann ES, Goldstein JA, Bastarache L, Pulley JM, and Aronoff DM. “EHRs could clarify drug safety in pregnant people.” Nature Medicine 26:820-821 (2020)
30. Challa AP, Beam AL, Shen M, Peryea T, Lavieri RR, Goldstein JA, Shirey-Rice JK, Lippmann ES, and Aronoff DM. “Machine learning on drug-specific data to predict small molecule teratogenicity.” Reproductive Toxicology 95:158-168 (2020)
29. O’Grady BJ and Lippmann ES. “Recent advancements in engineering strategies for manipulating neural stem cell behavior.” Current Tissue Microenvironment Reports 1:41-47 (2020)
28. Brown JA, Faley SL, Shi Y, Hillgren KM, Baker TK, Wikswo JP*, and Lippmann ES*. “Advances in blood-brain barrier modeling in microphysiological systems highlight critical differences in opioid transport due to cortisol exposure.” Fluids Barriers CNS 17:38 (2020). (* Co-corresponding author)
27. Rosch JC, Balikov DA, Gong F, and Lippmann ES. “A SELEX workflow with consolidated counterselection to efficiently isolate high affinity aptamers.” Engineering Reports 2:e12089 (2020).
26. Robertson G, Romero-Morales AI, Lippmann ES, and Gama V. “Uncovering cell biology in the third dimension.” Molecular Biology of the Cell 31:319-323 (2020).
25. Balikov DA, Neal EH, and Lippmann ES. “Organotypic neurovascular models: past results and future directions.” Trends in Molecular Medicine 26:273-284 (2020).
2019
24. Chasman D, Iyer N, Siahpirani AF, Estevez-Silva M, Lippmann E, McIntosh B, Probasco MD, Jiang P, Stewart RM, Thomson JA, Ashton RS, and Roy S. “Inferring regulatory programs governing region specificity of neuroepithelial stem cells during early hindbrain and spinal cord development.” Cell Systems 9:167-186 (2019). (* Co-corresponding author)
23. O’Grady BJ#, Balikov DA#, Lippmann ES*, and Bellan LM*. “Spatiotemporal control of morphogen delivery to pattern stem cell differentiation in three-dimensional hydrogels.” Current Protocols in Stem Cell Biology. 51:e97 (2019). (# Co-first author) (* Co-corresponding author)
22. Romero-Morales AI#, O’Grady BJ#, Balotin KM, Bellan LM, Lippmann ES*, and Gama V*. “Spin∞: an updated miniaturized spinning bioreactor design for the generation of human cerebral organoids from pluripotent stem cells.” HardwareX 6:e00084 (2019). (# Co-first author) (* Co-corresponding author)
21. Neal EH, Marinelli NA, Shi Y, McClatchey PM, Balotin KM, Gullett DR, Hagerla KA, Bowman AB, Ess KC, Wikswo JP, and Lippmann ES. “A simplified, fully defined differentiation scheme for producing blood-brain barrier endothelial cells from human iPSCs.” Stem Cell Reports 12:1380-1388 (2019).
20. Bakooshli MA, Lippmann ES, Mulcahy B, Iyer NR, Nguyen CT, Tung K, Stewart BA, van den Dorpel H, Fuehrmann T, Shoichet MS, Bigot A, Pegoraro E, Ahn H, Ginsberg H, Zhen M, Ashton RS, and Gilbert PM. “A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction.” eLife 8:e44350 (2019).
19. O’Grady BJ, Balikov DA, Wang JX, Neal EH, Ou Y, Bardhan R, Lippmann ES, and Bellan LM. “Spatiotemporal control and modeling of morphogen delivery to induce gradient patterning of stem cell differentiation using fluidic channels.” Biomaterials Science. 7:1358-1371 (2019).
18. Faley SL#, Neal EH#, Wang JX, Bosworth AM, Weber CM, Balotin KM, Lippmann ES*, and Bellan LM*. “iPSC-derived brain endothelium exhibits stable, long-term barrier function in perfused hydrogel scaffolds.” Stem Cell Reports. 12:474-487 (2019). (# Co-first author) (* Co-corresponding author)
17. Chiou B, Neal EH, Bowman AB, Lippmann ES, Simpson IA, and Connor JR. "Endothelial cell are critical regulators of iron transport in a model of the human blood-brain barrier." Journal of Cerebral Blood Flow and Metabolism 39:2117-2131 (2019).
2018
16. Ou Y, Webb JA, O’Brien CM, Pence IJ, Lin EC, Paul EP, Cole D, Ou SH, Lapierre-Landry M, DeLapp RC, Lippmann ES, Mahadevan-Jansen A, and Bardhan R. “Diagnosis of immunomarkers in vivo via multiplexed surface enhanced Raman imaging with multibranched gold nanoantennas.” Nanoscale. 10:13092-13105 (2018).
15. Chiou B, Neal EH, Bowman AB, Lippmann ES, Simpson IA, and Connor JR. "Pharmaceutical iron formulations do not cross a model of the human blood-brain barrier." PLoS One 13:e0198775 (2018).
14. O'Grady B, Wang J, Faley S, Balikov D, Lippmann E, and Bellan L. "A customizable, low-cost perfusion system for sustaining tissue constructs." SLAS Technology. 23:592-598 (2018).
13. Stebbins MJ, Lippmann ES, Faubion MG, Daneman R, Palecek SP, and Shusta EV. “Activation of RARα, RARγ, and RXRα can induce blood-brain barrier phenotypes in human pluripotent stem cell-derived brain endothelial cells.” Biotechnology Journal 13:1700093 (2018).
12. Bosworth AM, Faley SL, Bellan LM, and Lippmann ES. “Modeling neurovascular disorders and therapeutic outcomes with human induced pluripotent stem cells.” Frontiers in Bioengineering and Biotechnology 30:87 (2018).
2017
11. Hollmann EK, Bailey AK, Potharazu AV, Neely MD, Bowman AB, and Lippmann ES. “Accelerated differentiation of human induced pluripotent stem cells to blood-brain barrier endothelial cells.” Fluids Barriers CNS 14:9 (2017).
2016
10. Rosch JC*, Hollmann EK*, and Lippmann ES. “In vitro selection technologies to enhance biomaterial functionality.” Experimental Biology and Medicine 241:962-971 (2016). (* Equal contributions)
2015 and earlier (Pre-vanderbilt)
9. Lippmann ES, Williams CE, Ruhl DA, Estevez-Silva MC, Chapman ER, Coon JJ, and Ashton RS. “Deterministic HOX patterning in human pluripotent stem cell-derived neuroectoderm.” Stem Cell Reports 4:632-644 (2015).
8. Lippmann ES, Al-Ahmad A, Azarin SM, Palecek SP, and Shusta EV. “A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources.” Scientific Reports 4:4160 (2014).
7. Lippmann ES, Estevez-Silva MC, and Ashton RS. “Defined human pluripotent stem cell culture enables highly efficient neuroepithelium derivation independent of small molecule inhibitors.” Stem Cells 32:1032-1042 (2014).
6. Sha J, Lippmann ES, McNulty J, Ma Y, and Ashton RS. “Sequential nucleophilic substitutions permit orthogonal click functionalization of multicomponent PEG brushes.” Biomacromolecules 14:3294-3303 (2013).
5. Lippmann ES, Al-Ahmad A, Palecek SP, and Shusta EV. “Modeling the blood-brain barrier using stem cell sources.” Fluids Barriers CNS 10:1-14 (2013).
4. Lippmann ES*, Azarin SM*, Kay JE, Nessler RA, Wilson HK, Al-Ahmad A, Palecek SP, and Shusta EV. “Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells.” Nature Biotechnology 30:783-791 (2012). (* Equal contributions)
3. Lippmann ES, Weidenfeller C, Svendsen CN, and Shusta EV. “Blood-brain barrier modeling with co-cultured neural progenitor cell-derived astrocytes and neurons.” Journal of Neurochemistry 119:507-520 (2011).
2. Agarwal N, Lippmann ES, and Shusta EV. “Identification and expression profiling of blood-brain barrier membrane proteins.” Journal of Neurochemistry 112:625-635 (2010).
1. Usrey ML, Lippmann ES, and Strano MS. “Evidence of a two-step mechanism in electronically selective single-walled carbon nanotube reactions.” Journal of the American Chemical Society 127:16129-16135 (2005).