Biomaterials for regenerative therapy
Based on our promising cell culture work with peptide-functionalized gelatin hydrogels, we have been transitioning this class of biomaterials in vivo for regenerative therapy. In early work, we converted our “GelMA-Cad” hydrogel to an injectable formulation by removing the methacrylate group and using a reactive 4-arm PEG for in situ crosslinking. This “GelCad” hydrogel variant improved growth of perfusable arterioles relative to naked gelatin and could ameliorate tissue damage in a mouse model of critical limb ischemia when delivered immediately after femoral artery ligation surgery. We are now exploring additional peptide functionalities to increase vascular growth and density and to activate other signaling pathways that are important for tissue repair. We are also examining the potential of these hydrogels for cell replacement therapies in the brain.
Relevant contacts
Corinne Curry, Nicole Marguerite
Relevant publications