Graduate students (updated October 2018)
We are actively looking for talented graduate students to join our group. Students must first be accepted to the graduate program at Vanderbilt. We currently recruit students through ChBE, BME, QCB, and IGP. Please contact Dr. Lippmann at firstname.lastname@example.org with inquiries.
Postdoctoral researchers (updated december 2018)
Based on recently funded grants, we are actively recruiting postdoctoral researchers in the following areas:
Stem cell differentiation with multi-omic analyses
Human induced pluripotent stem cells (iPSCs) hold great promise for cell replacement therapy, but a key challenge is reproducible manufacturing of desired progenies. One challenge is monitoring cell identity in real-time in a non-destructive manner and without genetic modifications, such that workflows can be generically applied to any iPSC line. This project, which involves a multi-investigator consortium, seeks to determine if cell identity can be monitored throughout the differentiation process using mass spectrometry analysis of the secretome. Multiple neuroectodermal and mesodermal lineages will be patterned and analyzed as part of defined project milestones.
High throughput interrogation of blood-brain barrier phenotypes
Although many key differences in gene expression between blood-brain barrier (BBB) and peripheral endothelium have been identified, linking these genes to specific functions and BBB signaling networks in health and disease remains challenging. We are designing and implementing a number of siRNA and CRISPR screens in brain endothelial cells that will shed light on how the passive and active BBB phenotype is regulated. This project is open-ended and can be extended into several different areas based on interest and initial results.
Investigations of neurovascular function and disease mechanisms in vitro and in vivo
In conjunction with ongoing genetic screens, we have used targeted interrogations to identify a number of genes and signaling pathways that may be important for BBB function in health and disease. This project seeks to understand links between these genes/pathways (as well as relevant hits from the screens) and neurovascular disease/neurodegeneration. Research directions may include in vitro studies in engineered tissue constructs and in vivo studies in model organisms.
These positions are immediately available. Candidates must have a PhD or equivalent with strong research experience in any area pertaining to mammalian cell biology, engineering, chemistry, biochemistry, and neuroscience. Candidates with experience in in vitro CRISPR screening or in vivo neurovascular biology are particularly encouraged to apply. However, due to the wide breadth and scope of our research program, we value applications from a wide variety of backgrounds and research experiences, as long as the candidates are productive, hardworking, and self-motivated. Candidates are expected to be highly motivated, have excellent technical and communication skills, work effectively in a team-based environment while also performing self-directed research, and assist the PI in preparing manuscripts. Because each of these projects is part of larger initiatives, candidates will also be expected to train and partially supervise younger graduate students while coordinating research efforts. To apply, please email the following materials to Dr. Lippmann:
Brief description of research achievements, specific interests in one or more of the above projects, and how working with us will help facilitate career goals
List of 2-3 references
Undergraduate students (updated October 2018)
We are currently at capacity for undergraduate researchers. Please check back at a later time for new opportunities.